Endocrine Abstracts

Introduction: Leydig cell hypoplasia (LCH) is a rare autosomal recessive condition that interferes with normal development of male external genitalia in 46,XY individuals. It is mediated by mutations in the luteinizing hormone receptor gene (LHCGR), most frequently located in the coding sequence, resulting in impairment of either LH/CG binding or signal transduction.Case report: We report a 32-year-old female which presented with primary amenorrhea, fema...

Objective: To examine whether prolactinoma patients have an altered personality profile.Methods: In this cross-sectional study 84 prolactinoma patients were enrolled. As reference groups, we compared 58 patients with non-functioning pituitary adenomas and secondly 168 age and gender matched healthy control subjects. Personality traits were measured with the standardized Eysenck (EPQ) and Cloninger personality (TPQ) questionnaires.R...

Introduction: Treatment with dopamine agonists in patients with PRL adenomas has been associated with weight loss in short-term studies. However, long-term studies on weight changes are lacking. Taq1A is a restriction fragment length polymorphism considered as a gene marker for the D2DR gene. The presence of at least one A1 allele is linked to reduced brain dopaminergic activity due to reduced receptor binding and lower density of the dopamine two receptor.<p clas...

Introduction: Clinical presentation of pituitary adenomas frequently involves pain, particularly headache, probably due to both structural and functional properties of the tumour.Design: In a retrospective analysis, we investigated clinical characteristics of pain in 277 patients with pituitary disease (n=81 acromegaly; n=50 Cushing’s disease; n=86 prolactinoma; n=60 non-functioning pituitary adenoma). Specific pa...